In the U.S., tobacco kills more Americans than AIDS, alcohol, car accidents, murders, suicides, drugs, and fires combined.
"The Health Consequences of Smoking—50 Years of Progress. A Report of the Surgeon General." U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. Smoking-Attributable Morbidity, Mortality, and Economic Costs. 2014. Report.
http://www.surgeongeneral.gov/library/reports/50-years-of-progress/sgr50-chap-12.pdf
Murphy, Sherry L., et al. "Deaths: Final Data for 2010." U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 61(4). 08 May 2013. Report.