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Fact

Anhedonia could be considered a clinically significant and independent tobacco withdrawal symptom.

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Source 1:

Benowitz NL. Nicotine addiction. N Engl J Med. 2010;362(24):2295-2303. doi:10.1056/NEJMra0809890

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928221/

Source 2:

Benowitz NL. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics. Annu Rev Pharmacol Toxicol. 2009;49:57-71. doi:10.1146/annurev.pharmtox.48.113006.094742

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946180/

Source 3:

Hughes JR, Klemperer EM, Peasley-Miklus C. Possible New Symptoms of Tobacco Withdrawal II: Anhedonia-A Systematic Review. Nicotine Tob Res. 2020;22(1):11-17. doi:10.1093/ntr/nty171

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297016/

Source 4:

Cook JW, Piper ME, Leventhal AM, Schlam TR, Fiore MC, Baker TB. Anhedonia as a component of the tobacco withdrawal syndrome. J Abnorm Psychol. 2015;124(1):215-225. doi:10.1037/abn0000016

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348025/

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